Ukulandelana kwesikhathi eside kwe-COVID-19

U-Jennifer Mihas wayejwayele ukuphila impilo esebenzayo, edlala ithenisi futhi ehambahamba e-Seattle.Kepha ngoMashi 2020, wahlolwa ukuthi une-COVID-19 futhi ubelokhu egula kusukela lapho.Ngaleso sikhathi wayesekhathele ukuhamba amakhulu amayadi, futhi wayenenkinga yokuphefumula, imigraines, arrhythmias nezinye izimpawu eziqeda amandla.

Akuwona amacala ahlukile lawa.Ngokusho kwe-US Centers for Disease Control and Prevention, amaphesenti ayi-10 kuye kwangama-30 abantu abangenwe yi-SARS-CoV-2 baba nezinkinga zempilo zesikhathi eside.Abaningi babo njengoMihas, lezi zimpawu eziphikelelayo, ezaziwa ngokuthi yi-acute sequelae yokutheleleka kwe-SARS-CoV-2 (PASC) noma, imvamisa, ukulandelana kwesikhathi eside kwe-COVID-19, kungaba mnene noma kuqine ngokwanele ukukhubaza, okuthinta cishe zonke izitho zomzimba emzimbeni.

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Abantu abathintekile bavame ukubika ukukhathala okukhulu nobuhlungu bomzimba.Abantu abaningi balahlekelwa umuzwa wabo wokunambitha noma wokuhogela, ubuchopho babo buyancipha futhi abakwazi ukugxilisa ingqondo, okuyinkinga evamile.Ochwepheshe bakhathazekile ngokuthi ezinye iziguli ezine-sequelae yesikhathi eside ye-COVID-19 zingase zingalulami.

Manje, ukulandelana kwesikhathi eside kwe-COVID-19 kuya ngokuya kubhekwe obala.NgoFebhuwari, iNATIONAL Institutes of Health yamemezela uhlelo luka-$1.15 billion lokunquma izimbangela zokulandelana kwesikhathi eside kwe-COVID-19 nokuthola izindlela zokuvimbela nokwelapha lesi sifo.

Ekupheleni kukaJuni, bangaphezu kwezigidi eziyi-180 abantu asebehlolwe ukuthi bane-SARS-CoV-2, kanti amakhulu ezigidi ngaphezulu kungenzeka ukuthi angenwe yi-SARS-CoV-2, kanti kwakhiwa imishanguzo emisha yokubhekana nenani elikhulu labantu. izinkomba ezintsha ezingaba khona kwezokwelapha.

I-PureTech Health yenza uhlolo lomtholampilo lwesigaba II sefomu ehoxisiwe ye-pirfenidone, i-LYT-100.I-Pirfenidone ivunyelwe i-idiopathic pulmonary fibrosis.I-Lyt-100 ihlose ama-cytokines ane-pro-inflammatory, okuhlanganisa i-IL-6 ne-TNF-α, futhi yehlisa ukusayinda kwe-TGF-β ukuvimba ukufakwa kwe-collagen nokwakheka kwezibazi.

I-CytoDyn ihlola umphikisi wayo we-CC motactic chemokine receptor 5 (CCR5) i-leronlimab, i-IgG4 yomuntu elwa ne-monoclonal, esivivinyweni sesigaba 2 sabantu abangu-50.I-CCR5 ibandakanyeka ezinqubweni eziningi zezifo, okuhlanganisa i-HIV, i-multiple sclerosis, nomdlavuza we-metastatic.I-Leronlimab ihlolwe ezivivinyweni zomtholampilo zesigaba 2B/3 njengokwelashwa okwengeziwe kwesifo sokuphefumula ezigulini ezigula kakhulu ezine-COVID-19.Imiphumela iphakamisa ukuthi umuthi unenzuzo yokusinda uma uqhathaniswa nokwelashwa okuvame ukusetshenziswa, futhi ucwaningo lwamanje lwesigaba 2 luzophenya umuthi njengokwelashwa kwezinhlobo eziningi zezimpawu.

I-Ampio Pharmaceuticals ibike imiphumela emihle yesigaba 1 se-cyclopeptide yayo i-LMWF5A (aspartic alanyl diketopiperazine), elapha ukuvuvukala okudlulele emaphashini, futhi u-Ampio uthi i-peptide ikhulise zonke izizathu zokufa ezigulini ezinokucindezeleka kokuphefumula.Ocwaningweni olusha lweSigaba 1, iziguli ezinezimpawu zokuphefumula ezihlala amasonto amane noma ngaphezulu zizozinikeza i-nebulizer ekhaya izinsuku ezinhlanu.

I-Synairgen yase-United Kingdom yasebenzisa indlela efanayo ukuze yengeze ukulandelana kwe-COVID-19 yesikhathi eside esivivinyweni somtholampilo sesigaba sesi-3 se-SNG001 (ehogelwe i-IFN-β).Imiphumela evela ocwaningweni lwesigaba 2 somuthi ibonise ukuthi i-SNG001 yayinenzuzo ekuthuthukisweni kwesiguli, ukutakula, nokukhululwa uma kuqhathaniswa ne-placebo ngosuku lwe-28.


Isikhathi sokuthumela: 26-08-21