Buyini ubudlelwano phakathi kokudangala kwabaneminyaka ephakathi kanye ne-Tau deposition?

Ngokocwaningo olusha olwenziwa abacwaningi base-UT Health San Antonio kanye nezikhungo ezibambisene nabo, abantu abaneminyaka ephakathi abanezimpawu zokucindezeleka baphatha amaprotheni okuthiwa i-APOE.Ukuguqulwa kwezinguquko ku-epsilon 4 Kungase kube maningi amathuba okuba kukhiqize i-tau buildup ezindaweni zobuchopho ezilawula isimo sengqondo nenkumbulo.

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Okutholakele kushicilelwe kumagazini kaJuni 2021 weJournal of Alzheimer's Disease.Ucwaningo lwalusekelwe ekuhloleni ukucindezeleka kanye nesithombe se-positron emission tomography (PET) sabahlanganyeli abangu-201 ku-multigenerational Framingham Heart Study.Isilinganiso seminyaka yabahlanganyeli sasingama-53.

Amathuba okuthola lesi sifo amashumi eminyaka ngaphambi kokuxilongwa

I-PET ivame ukwenziwa kubantu abadala asebekhulile, ngakho-ke i-Framingham STUDY ku-PET eneminyaka ephakathi ihlukile, kusho uMitzi M. Gonzales, umbhali oholayo walolu cwaningo kanye ne-neuropsychologist e-Glenn Biggs Institute for Alzheimer's disease and Neurodegenerative Diseases, eyingxenye yocwaningo. I-University of Texas Health Centre e-SAN Antonio.

"Lokhu kusinika ithuba elithakazelisayo lokufunda abantu abaneminyaka ephakathi futhi siqonde izici ezingase zihlotshaniswe nokuqoqwa kwamaprotheni kubantu abavamile ngokomqondo," kusho uDkt. Gonzales."Uma laba bantu beqhubeka nokuba nokuwohloka komqondo, lolu cwaningo luzodalula lawo mathuba emashumini eminyaka ngaphambi kokuxilongwa."

Ayihlangene ne-beta-amyloid

I-Beta-amyloid (Aβ) kanye ne-Tau angamaprotheni anqwabelana ebuchosheni babantu abanesifo i-Alzheimer futhi ngokuvamile anda ngobumnene nangokukhula.Ucwaningo alutholanga ukuhlobana phakathi kwezimpawu zokucindezeleka nokudangala kanye ne-beta-amyloid.Yayihlotshaniswa ne-Tau kuphela, futhi kuphela nabathwali be-APOE ε4 mutation.Cishe ingxenye yesine yeziguli ezingu-201 (47) zaziphethe isakhi sofuzo esingu-ε4 ngoba okungenani zine-allele eyodwa engu-ε4.

Ukuthwala ikhophi eyodwa yofuzo lwe-APOEε4 kwandisa ubungozi besifo i-alzheimer ngokuphindwe kabili kuya kokuthathu, kodwa abanye abantu abaphethe okuhlukile kwesakhi sofuzo bangaphila kuze kube yiminyaka engama-80 noma engu-90 ngaphandle kokuthola isifo.“Kubalulekile ukukhumbula ukuthi ngenxa yokuthi umuntu ubonakala ephethe i-APOE ε4 akusho ukuthi uzophathwa ukuwohloka komqondo esikhathini esizayo,” kusho uDkt. Gonzales.Kusho ukuthi izibalo ziphezulu."

Izimpawu zokucindezeleka (ukucindezeleka uma izimpawu zinzima ngokwanele ukuhlangabezana nalesi simo sokuxilonga) zahlolwa ngesikhathi se-PET imaging kanye neminyaka eyisishiyagalombili ngaphambi kokusebenzisa i-Epidemiological Research Center Depression Scale.Izimpawu zokucindezeleka kanye nokuhlangana phakathi kokucindezeleka kanye nemiphumela ye-PET ngezikhathi ezimbili zahlolwa, zalungiselelwa ubudala nobulili.

Izikhungo zemizwa nezokuqonda

Ucwaningo lubonise ukuhlobana phakathi kwezimpawu zokucindezeleka kanye nokwanda kwe-tau ezifundeni ezimbili zobuchopho, i-entorhinal cortex kanye ne-amygdala."Lezi zinhlangano azisho ukuthi ukuqoqwa kwe-tau kubangela izimpawu ezicindezelayo noma okuphambene nalokho," kusho uDkt. Gonzales."Siqaphele lezi zinto ezimbili kuphela ezithwalweni ze-ε4."

Waphawula ukuthi i-entorhinal cortex ibalulekile ekuhlanganiseni inkumbulo futhi ivame ukuba yindawo lapho ukufakwa kwamaprotheni kwenzeka kusenesikhathi.Phakathi naleso sikhathi, i-amygdala kucatshangwa ukuthi iyisikhungo semizwa sobuchopho.

"Izifundo ze-Longitudinal ziyadingeka ukuze kuthuthukiswe ukuqonda okwenzekayo, kodwa kuyathakazelisa ukucabanga ngemiphumela yomtholampilo yalokho esikutholile mayelana nokulawulwa kwengqondo kanye nemizwelo," kusho uDkt. Gonzales.


Isikhathi sokuthumela: 26-08-21